Cell Line Development

• Adaptation of cell lines to serum free media
• Conversion of adherent growing cells into suspension cell lines
• Optimisation of glycosylation pattern

Fermentation in a stirred tank fermenter is the most widespread method for the production of recombinant proteins in cell cultures. Various methods such as batch, fed-batch, repeated batch and perfusion are well established at Glycotope Biotechnology.

Our core competencies:

• Production, characterization and storage of Master and Working Cell Banks (MCB/WCB)
• Scale-up to production levels, fermenter volume: 10 – 300 Liter
• Cultivation in perfusion mode: 7,500 Liter batch size

Cell cultivation processes are performed in a monitored hygienic area corresponding to ISO class 8. Our facility encompasses 4 separate fermentation suites.